A lymphocyte that can spontaneously kill a variety of target cells without prior antigenic activation via germline encoded activation receptors and also regulate immune responses via cytokine release and direct contact with other cells.
A natural killer cell that is developmentally immature and expresses natural killer cell receptors (NKR).
In mouse the NKR are Ly49 molecules and in human these cells express KIR molecules.
A natural killer cell that is developmentally mature and expresses a variety of inhibitory and activating receptors that recognize MHC class I and other stress related molecules.
Cell committed to natural killer cell lineage that has the phenotype CD122-positive, CD34-positive, and CD117-positive. This cell type lacks expression of natural killer receptor proteins.
These cells are also reportedly CD7-low, CD10-negative, CD45RA-positive, alpha-4-beta-7 integrin-high.
A lymphocyte that lacks characteristic T cell, B cell, myeloid cell, and dendritic cell markers, that functions as part of the innate immune response to produce cytokines and other effector responses.
An innate lymphoid cell that is capable of producing the type 1 cytokine IFN-gamma, but not Th2 or Th17 cell-associated cytokines.
A group 1 innate lymphoid cell that is non-cytotoxic.
An innate lymphoid cell that is capable of producing T-helper 2-cell associated cytokines upon stimulation.
An innate lymphoid cell that constituitively expresses RORgt and is capable of expressing IL17A and/or IL-22.
An innate lyphoid cell with an immature phenotype.
A group 2 innate lymphoid cell in the mouse capable of secreting IL-13 in response to a helminth infection. This cell is lineage-negative, ICOS-positive, IL1RL1-positive, IL7Ralpha-positive, and IL17Br-positive.
An immature natural killer cell that is NK1.1-positive, DX5-positive, Ly49-positive, CD27-low and CD11b-low. This cell type is found in high numbers in the liver.
Markers are associated with mouse cells.
CD27-low, CD11b-low immature natural killer cell
An immature natural killer cell that is NK1.1-positive and DX-5 negative.
Dx5-negative, NK1.1-positive immature natural killer cell
A mature natural killer cell that is CD27-high and CD11b-high. This cell type is capable of interferon-gamma secretion.
CD27-high, CD11b-high natural killer cell
A CD27-low, CD11b-high natural killer cell that has a higher threshold of activation due to higher expression of inhibitory receptors.
CD27-low, CD11b-high natural killer cell
A natural killer cell that is CD27-high and CD11b-low.
CD27-high, CD11b-low natural killer cell
A mature natural killer cell that is CD11b-positive and CD27-positive.
A natural killer cell that is NK1.1-positive, CD11b-positive, and CD27-positive.
CD11b-positive, CD27-positive natural killer cell
A mature NK cell that is NK1.1-positive.
Note: Nk1.1 expression is restricted to C57BL strains of laboratory mice.
A NK1.1-positive T cell that is NKGA2-positive.
A NK1.1-positive T cell that is Ly49D-positive.
A NK1.1-positive T cell that is CD94-positive.
A NK1.1-positive T cell that is CD94-negative and Ly49Cl-negative.
CD94-negative, Ly49CI-negative natural killer cell
A NK1.1-positive T cell that is Ly49Cl-positive.
A NK1.1-positive T cell that is Ly49H-positive.
A NK1.1-positive T cell that is Ly49D-negative.
A NK1.1-positive T cell that is Ly49Cl-negative.
A NK1.1-positive T cell that is CD94-negative.
A NK1.1-positive T cell that is Ly49H-negative.
A NK1.1-positive T cell that is CD94-positive and Ly49Cl-positive.
CD94-positive Ly49CI-positive natural killer cell
A large, granular, liver specific natural killer cell that adheres to the endothelial cells of the hepatic sinusoid.
Pit cells are named for the presence of large cytoplasmic granules that resemble pits (pips) of fruit.
positive regulation of type 2 immune response
natural killer cell mediated cytotoxicity
T-cell surface glycoprotein CD8 alpha chain
membrane-spanning 4-domains subfamily A member 1
killer cell lectin-like receptor subfamily D member 1
low affinity immunoglobulin gamma Fc region receptor III
natural cytotoxicity triggering receptor 1
MHC class II histocompatibility antigen alpha chain DRA
NKG2-A/NKG2-B type II integral membrane protein
killer cell lectin-like receptor subfamily B member 1C
high affinity immunoglobulin epsilon receptor subunit alpha
natural cytotoxicity triggering receptor 1 (human)
natural cytotoxicity triggering receptor 2 (human)
interleukin-2 receptor subunit alpha (human)
mast/stem cell growth factor receptor Kit (human)
interleukin-7 receptor subunit alpha (human)
trans-acting T-cell-specific transcription factor GATA-3 (human)
hematopoietic progenitor cell antigen CD34 (human)
killer cell lectin-like receptor subfamily B member 1 (human)
killer cell lectin-like receptor subfamily G member 1 (human)
T-box transcription factor TBX21 (human)