definition
type: AnnotationProperty

created_by
type: AnnotationProperty

creation_date
type: AnnotationProperty

database_cross_reference
type: AnnotationProperty

has_broad_synonym
type: AnnotationProperty

has_exact_synonym
type: AnnotationProperty

has_obo_namespace
type: AnnotationProperty

has_related_synonym
type: AnnotationProperty

has part
type: ObjectProperty

bearer of
type: ObjectProperty

located in
type: ObjectProperty

has plasma membrane part
type: ObjectProperty
sub property of: has part

only in taxon
type: ObjectProperty
sub property of: in taxon

in taxon
type: ObjectProperty

develops from
type: ObjectProperty

capable of
type: ObjectProperty

has_high_plasma_membrane_amount
type: ObjectProperty
sub property of: has plasma membrane part

has_low_plasma_membrane_amount
type: ObjectProperty
sub property of: has plasma membrane part

lacks part
type: ObjectProperty

lacks_plasma_membrane_part
type: ObjectProperty

neutrophillic cytoplasm
type: Class
subclass of: cell part

increased nucleus size
type: Class
subclass of: cell part

cell
type: Class
subclass of: Thing

lymphocyte
type: Class
subclass of: cell

natural killer cell
type: Class
equivalent class: Class
  intersection of: group 1 innate lymphoid cell
  intersection of: Restriction
    on property: capable of
    some values from: natural killer cell mediated immunity
  intersection of: Restriction
    on property: capable of
    some values from: regulation of immune response
  intersection of: Restriction
    on property: lacks_plasma_membrane_part
    some values from: CD19 molecule
  intersection of: Restriction
    on property: lacks_plasma_membrane_part
    some values from: CD3 epsilon
  intersection of: Restriction
    on property: lacks_plasma_membrane_part
    some values from: membrane-spanning 4-domains subfamily A member 1
  intersection of: Restriction
    on property: lacks_plasma_membrane_part
    some values from: CD14 molecule
subclass of: group 1 innate lymphoid cell
subclass of: Restriction
  on property: develops from
  some values from: pro-NK cell
definition: A lymphocyte that can spontaneously kill a variety of target cells without prior antigenic activation via germline encoded activation receptors and also regulate immune responses via cytokine release and direct contact with other cells.
database_cross_reference: BTO:0000914
database_cross_reference: BTO:0004716
database_cross_reference: CALOHA:TS-0664
database_cross_reference: FMA:63147
database_cross_reference: FMA:83601
database_cross_reference: VHOG:0001697
has_broad_synonym: large granular lymphocyte
has_broad_synonym: null cell
has_exact_synonym: NK cell
has_obo_namespace: cell

Axiom
annotated source: natural killer cell
annotated property: definition
annotated target: A lymphocyte that can spontaneously kill a variety of target cells without prior antigenic activation via germline encoded activation receptors and also regulate immune responses via cytokine release and direct contact with other cells.
database_cross_reference: GOC:add
database_cross_reference: ISBN:0781735149
database_cross_reference: PMID:15771571

immature natural killer cell
type: Class
equivalent class: Class
  intersection of: natural killer cell
  intersection of: Restriction
    on property: bearer of
    some values from: immature
subclass of: natural killer cell
subclass of: immature innate lymphoid cell
subclass of: Restriction
  on property: develops from
  some values from: pre-natural killer cell
disjoint with: mature natural killer cell
disjoint with: pre-natural killer cell
definition: A natural killer cell that is developmentally immature and expresses natural killer cell receptors (NKR).
has_exact_synonym: immature NK cell
has_obo_namespace: cell
has_related_synonym: p-NK
comment: In mouse the NKR are Ly49 molecules and in human these cells express KIR molecules.

Axiom
annotated source: immature natural killer cell
annotated property: definition
annotated target: A natural killer cell that is developmentally immature and expresses natural killer cell receptors (NKR).
database_cross_reference: GOC:add
database_cross_reference: GO_REF:0000031
database_cross_reference: ISBN:0781735149
database_cross_reference: PMID:12457618

Axiom
annotated source: immature natural killer cell
annotated property: has_related_synonym
annotated target: p-NK
database_cross_reference: PMID:12457618

mature natural killer cell
type: Class
subclass of: natural killer cell
subclass of: Restriction
  on property: develops from
  some values from: immature natural killer cell
definition: A natural killer cell that is developmentally mature and expresses a variety of inhibitory and activating receptors that recognize MHC class I and other stress related molecules.
has_broad_synonym: LAK cell
has_broad_synonym: lymphokine activated killer cell
has_exact_synonym: mature NK cell
has_obo_namespace: cell

Axiom
annotated source: mature natural killer cell
annotated property: definition
annotated target: A natural killer cell that is developmentally mature and expresses a variety of inhibitory and activating receptors that recognize MHC class I and other stress related molecules.
database_cross_reference: GOC:add
database_cross_reference: GO_REF:0000031
database_cross_reference: ISBN:0781735149
database_cross_reference: PMID:14685782

Axiom
annotated source: mature natural killer cell
annotated property: has_broad_synonym
annotated target: LAK cell
database_cross_reference: PMID:14685782

Axiom
annotated source: mature natural killer cell
annotated property: has_broad_synonym
annotated target: lymphokine activated killer cell
database_cross_reference: PMID:14685782

pro-NK cell
type: Class
subclass of: cell

pre-natural killer cell
type: Class
equivalent class: Class
  intersection of: natural killer cell
  intersection of: Restriction
    on property: has plasma membrane part
    some values from: CD34 molecule
  intersection of: Restriction
    on property: has plasma membrane part
    some values from: interleukin-2 receptor subunit beta
  intersection of: Restriction
    on property: has plasma membrane part
    some values from: mast/stem cell growth factor receptor
subclass of: natural killer cell
definition: Cell committed to natural killer cell lineage that has the phenotype CD122-positive, CD34-positive, and CD117-positive. This cell type lacks expression of natural killer receptor proteins.
has_exact_synonym: pre-NK cell
has_obo_namespace: cell
comment: These cells are also reportedly CD7-low, CD10-negative, CD45RA-positive, alpha-4-beta-7 integrin-high.

Axiom
annotated source: pre-natural killer cell
annotated property: definition
annotated target: Cell committed to natural killer cell lineage that has the phenotype CD122-positive, CD34-positive, and CD117-positive. This cell type lacks expression of natural killer receptor proteins.
database_cross_reference: GOC:add
database_cross_reference: GOC:dsd
database_cross_reference: GOC:pam
database_cross_reference: GOC:tfm
database_cross_reference: GO_REF:0000031
database_cross_reference: PMID:16551251
database_cross_reference: PMID:17100874

innate lymphoid cell
type: Class
equivalent class: Class
  intersection of: lymphocyte
  intersection of: Restriction
    on property: capable of
    some values from: cytokine production
  intersection of: Restriction
    on property: capable of
    some values from: innate immune response
  intersection of: Restriction
    on property: lacks_plasma_membrane_part
    some values from: CD19 molecule
  intersection of: Restriction
    on property: lacks_plasma_membrane_part
    some values from: CD3 epsilon
subclass of: lymphocyte
definition: A lymphocyte that lacks characteristic T cell, B cell, myeloid cell, and dendritic cell markers, that functions as part of the innate immune response to produce cytokines and other effector responses.
creator: http://orcid.org/0000-0001-9990-8331
date: 2017-01-30T20:20:48Z
has_obo_namespace: cell

Axiom
annotated source: innate lymphoid cell
annotated property: definition
annotated target: A lymphocyte that lacks characteristic T cell, B cell, myeloid cell, and dendritic cell markers, that functions as part of the innate immune response to produce cytokines and other effector responses.
database_cross_reference: GOC:add
database_cross_reference: GOC:dsd
database_cross_reference: PMID:23292121
database_cross_reference: PMID:23348417

group 1 innate lymphoid cell
type: Class
equivalent class: Class
  intersection of: innate lymphoid cell
  intersection of: Restriction
    on property: capable of
    some values from: interferon-gamma production
subclass of: innate lymphoid cell
definition: An innate lymphoid cell that is capable of producing the type 1 cytokine IFN-gamma, but not Th2 or Th17 cell-associated cytokines.
creator: http://orcid.org/0000-0001-9990-8331
date: 2017-01-30T20:42:44Z
has_obo_namespace: cell

Axiom
annotated source: group 1 innate lymphoid cell
annotated property: definition
annotated target: An innate lymphoid cell that is capable of producing the type 1 cytokine IFN-gamma, but not Th2 or Th17 cell-associated cytokines.
database_cross_reference: GOC:add
database_cross_reference: GOC:dsd
database_cross_reference: PMID:23348417

ILC1
type: Class
equivalent class: Class
  intersection of: group 1 innate lymphoid cell
  intersection of: Class
    complement of: Restriction
      on property: capable of
      some values from: leukocyte mediated cytotoxicity
subclass of: group 1 innate lymphoid cell
definition: A group 1 innate lymphoid cell that is non-cytotoxic.
creator: http://orcid.org/0000-0001-9990-8331
date: 2017-01-30T20:54:12Z
has_obo_namespace: cell

Axiom
annotated source: ILC1
annotated property: definition
annotated target: A group 1 innate lymphoid cell that is non-cytotoxic.
database_cross_reference: GOC:add
database_cross_reference: GOC:dsd
database_cross_reference: PMID:23292121
database_cross_reference: PMID:23348417

group 2 innate lymphoid cell
type: Class
equivalent class: Class
  intersection of: innate lymphoid cell
  intersection of: Restriction
    on property: capable of
    some values from: interleukin-5 production
subclass of: innate lymphoid cell
definition: An innate lymphoid cell that is capable of producing T-helper 2-cell associated cytokines upon stimulation.
creator: http://orcid.org/0000-0001-9990-8331
date: 2017-01-30T21:20:08Z
has_exact_synonym: ILC2
has_exact_synonym: nuocyte
has_obo_namespace: cell

Axiom
annotated source: group 2 innate lymphoid cell
annotated property: definition
annotated target: An innate lymphoid cell that is capable of producing T-helper 2-cell associated cytokines upon stimulation.
database_cross_reference: GOC:add
database_cross_reference: GOC:dsd
database_cross_reference: PMID:23292121
database_cross_reference: PMID:23562755

group 3 innate lymphoid cell
type: Class
equivalent class: Class
  intersection of: innate lymphoid cell
  intersection of: Restriction
    on property: has part
    some values from: nuclear receptor ROR-gamma isoform 2
subclass of: innate lymphoid cell
definition: An innate lymphoid cell that constituitively expresses RORgt and is capable of expressing IL17A and/or IL-22.
creator: http://orcid.org/0000-0001-9990-8331
date: 2017-01-31T20:21:26Z
has_exact_synonym: ILC3
has_obo_namespace: cell

Axiom
annotated source: group 3 innate lymphoid cell
annotated property: definition
annotated target: An innate lymphoid cell that constituitively expresses RORgt and is capable of expressing IL17A and/or IL-22.
database_cross_reference: GOC:add
database_cross_reference: GOC:dsd
database_cross_reference: PMID:23292121
database_cross_reference: PMID:23348417

immature innate lymphoid cell
type: Class
equivalent class: Class
  intersection of: innate lymphoid cell
  intersection of: Restriction
    on property: bearer of
    some values from: immature
subclass of: innate lymphoid cell
definition: An innate lyphoid cell with an immature phenotype.
has_exact_synonym: immature ILC

Axiom
annotated source: immature innate lymphoid cell
annotated property: definition
annotated target: An innate lyphoid cell with an immature phenotype.
database_cross_reference: GOC:add

group 2 innate lymphoid cell, mouse
type: Class
equivalent class: Class
  intersection of: group 2 innate lymphoid cell
  intersection of: Restriction
    on property: has plasma membrane part
    some values from: inducible T-cell costimulator
  intersection of: Restriction
    on property: has plasma membrane part
    some values from: interleukin-7 receptor subunit alpha
  intersection of: Restriction
    on property: has plasma membrane part
    some values from: interleukin-17 receptor B
  intersection of: Restriction
    on property: has plasma membrane part
    some values from: interleukin-1 receptor-like 1
  intersection of: Restriction
    on property: only in taxon
    some values from: Mus musculus
  intersection of: Restriction
    on property: capable of
    some values from: positive regulation of type 2 immune response
  intersection of: Restriction
    on property: capable of
    some values from: interleukin-13 production
  intersection of: Restriction
    on property: lacks_plasma_membrane_part
    some values from: CD19 molecule
  intersection of: Restriction
    on property: lacks_plasma_membrane_part
    some values from: CD4 molecule
  intersection of: Restriction
    on property: lacks_plasma_membrane_part
    some values from: integrin alpha-2
  intersection of: Restriction
    on property: lacks_plasma_membrane_part
    some values from: integrin alpha-M
  intersection of: Restriction
    on property: lacks_plasma_membrane_part
    some values from: CD3 epsilon
  intersection of: Restriction
    on property: lacks_plasma_membrane_part
    some values from: neural cell adhesion molecule 1
  intersection of: Restriction
    on property: lacks_plasma_membrane_part
    some values from: T-cell surface glycoprotein CD8 alpha chain
  intersection of: Restriction
    on property: lacks_plasma_membrane_part
    some values from: bone marrow stromal antigen 2
  intersection of: Restriction
    on property: lacks_plasma_membrane_part
    some values from: natural cytotoxicity triggering receptor 1
  intersection of: Restriction
    on property: lacks_plasma_membrane_part
    some values from: sialic acid-binding Ig-like lectin 5
  intersection of: Restriction
    on property: lacks_plasma_membrane_part
    some values from: high affinity immunoglobulin epsilon receptor subunit alpha
subclass of: group 2 innate lymphoid cell
definition: A group 2 innate lymphoid cell in the mouse capable of secreting IL-13 in response to a helminth infection. This cell is lineage-negative, ICOS-positive, IL1RL1-positive, IL7Ralpha-positive, and IL17Br-positive.
created_by: tmeehan
creation_date: 2010-08-12T02:22:19Z
has_broad_synonym: nuocyte
has_obo_namespace: cell

Axiom
annotated source: group 2 innate lymphoid cell, mouse
annotated property: definition
annotated target: A group 2 innate lymphoid cell in the mouse capable of secreting IL-13 in response to a helminth infection. This cell is lineage-negative, ICOS-positive, IL1RL1-positive, IL7Ralpha-positive, and IL17Br-positive.
database_cross_reference: GOC:add
database_cross_reference: GOC:tfm
database_cross_reference: PMID:20200518

CD27-low, CD11b-low immature natural killer cell
type: Class
equivalent class: Class
  intersection of: immature natural killer cell
  intersection of: Restriction
    on property: has plasma membrane part
    some values from: integrin alpha-2
  intersection of: Restriction
    on property: has plasma membrane part
    some values from: killer cell lectin-like receptor subfamily B member 1C
  intersection of: Restriction
    on property: has plasma membrane part
    some values from: T-cell surface glycoprotein YE1/48
  intersection of: Restriction
    on property: only in taxon
    some values from: Mus musculus
  intersection of: Restriction
    on property: has_low_plasma_membrane_amount
    some values from: integrin alpha-M
  intersection of: Restriction
    on property: has_low_plasma_membrane_amount
    some values from: CD27 molecule
subclass of: immature natural killer cell
subclass of: Restriction
  on property: develops from
  some values from: Dx5-negative, NK1.1-positive immature natural killer cell
definition: An immature natural killer cell that is NK1.1-positive, DX5-positive, Ly49-positive, CD27-low and CD11b-low. This cell type is found in high numbers in the liver.
created_by: tmeehan
creation_date: 2010-09-20T04:41:01Z
has_broad_synonym: preNK.BM
has_obo_namespace: cell
comment: Markers are associated with mouse cells.

Axiom
annotated source: CD27-low, CD11b-low immature natural killer cell
annotated property: definition
annotated target: An immature natural killer cell that is NK1.1-positive, DX5-positive, Ly49-positive, CD27-low and CD11b-low. This cell type is found in high numbers in the liver.
database_cross_reference: GOC:tfm
database_cross_reference: PMID:19949422
database_cross_reference: http:www.immgen.org/index_content.html

Dx5-negative, NK1.1-positive immature natural killer cell
type: Class
equivalent class: Class
  intersection of: immature natural killer cell
  intersection of: Restriction
    on property: has plasma membrane part
    some values from: killer cell lectin-like receptor subfamily B member 1C
  intersection of: Restriction
    on property: only in taxon
    some values from: Mus musculus
  intersection of: Restriction
    on property: lacks_plasma_membrane_part
    some values from: integrin alpha-2
subclass of: immature natural killer cell
definition: An immature natural killer cell that is NK1.1-positive and DX-5 negative.
created_by: tmeehan
creation_date: 2010-09-21T10:11:44Z
has_obo_namespace: cell

Axiom
annotated source: Dx5-negative, NK1.1-positive immature natural killer cell
annotated property: definition
annotated target: An immature natural killer cell that is NK1.1-positive and DX-5 negative.
database_cross_reference: GOC:tfm
database_cross_reference: PMID:12766763

CD27-high, CD11b-high natural killer cell
type: Class
equivalent class: Class
  intersection of: mature natural killer cell
  intersection of: Restriction
    on property: only in taxon
    some values from: Mus musculus
  intersection of: Restriction
    on property: capable of
    some values from: interferon-gamma production
  intersection of: Restriction
    on property: has_high_plasma_membrane_amount
    some values from: integrin alpha-M
  intersection of: Restriction
    on property: has_high_plasma_membrane_amount
    some values from: CD27 molecule
subclass of: CD11b-positive, CD27-positive natural killer cell
subclass of: Restriction
  on property: develops from
  some values from: CD27-high, CD11b-low natural killer cell
definition: A mature natural killer cell that is CD27-high and CD11b-high. This cell type is capable of interferon-gamma secretion.
created_by: tmeehan
creation_date: 2010-09-21T10:19:49Z
has_obo_namespace: cell

Axiom
annotated source: CD27-high, CD11b-high natural killer cell
annotated property: definition
annotated target: A mature natural killer cell that is CD27-high and CD11b-high. This cell type is capable of interferon-gamma secretion.
database_cross_reference: GOC:tfm
database_cross_reference: PMID:19949422

CD27-low, CD11b-high natural killer cell
type: Class
equivalent class: Class
  intersection of: mature natural killer cell
  intersection of: Restriction
    on property: only in taxon
    some values from: Mus musculus
  intersection of: Restriction
    on property: has_high_plasma_membrane_amount
    some values from: integrin alpha-M
  intersection of: Restriction
    on property: has_low_plasma_membrane_amount
    some values from: CD27 molecule
subclass of: CD11b-positive, CD27-positive natural killer cell
subclass of: Restriction
  on property: develops from
  some values from: CD27-high, CD11b-high natural killer cell
definition: A CD27-low, CD11b-high natural killer cell that has a higher threshold of activation due to higher expression of inhibitory receptors.
created_by: tmeehan
creation_date: 2010-09-21T10:19:54Z
has_obo_namespace: cell

Axiom
annotated source: CD27-low, CD11b-high natural killer cell
annotated property: definition
annotated target: A CD27-low, CD11b-high natural killer cell that has a higher threshold of activation due to higher expression of inhibitory receptors.
database_cross_reference: GOC:tfm
database_cross_reference: PMID:1994922

CD27-high, CD11b-low natural killer cell
type: Class
equivalent class: Class
  intersection of: mature natural killer cell
  intersection of: Restriction
    on property: only in taxon
    some values from: Mus musculus
  intersection of: Restriction
    on property: has_high_plasma_membrane_amount
    some values from: CD27 molecule
  intersection of: Restriction
    on property: has_low_plasma_membrane_amount
    some values from: integrin alpha-M
subclass of: CD11b-positive, CD27-positive natural killer cell
subclass of: Restriction
  on property: develops from
  some values from: CD27-low, CD11b-low immature natural killer cell
definition: A natural killer cell that is CD27-high and CD11b-low.
created_by: tmeehan
creation_date: 2010-09-21T10:20:00Z
has_obo_namespace: cell

Axiom
annotated source: CD27-high, CD11b-low natural killer cell
annotated property: definition
annotated target: A natural killer cell that is CD27-high and CD11b-low.
database_cross_reference: GOC:tfm
database_cross_reference: PMID:1994922

CD11b-positive, CD27-positive natural killer cell
type: Class
equivalent class: Class
  intersection of: NK1.1-positive natural killer cell
  intersection of: Restriction
    on property: has plasma membrane part
    some values from: integrin alpha-M
  intersection of: Restriction
    on property: has plasma membrane part
    some values from: CD27 molecule
  intersection of: Restriction
    on property: only in taxon
    some values from: Mus musculus
subclass of: NK1.1-positive natural killer cell
definition: A mature natural killer cell that is CD11b-positive and CD27-positive.
created_by: tmeehan
creation_date: 2010-10-25T03:07:59Z
has_obo_namespace: cell
comment: A natural killer cell that is NK1.1-positive, CD11b-positive, and CD27-positive.

Axiom
annotated source: CD11b-positive, CD27-positive natural killer cell
annotated property: definition
annotated target: A mature natural killer cell that is CD11b-positive and CD27-positive.
database_cross_reference: GOC:tfm
database_cross_reference: http://www.immgen.org/index_content.html

NK1.1-positive natural killer cell
type: Class
equivalent class: Class
  intersection of: mature natural killer cell
  intersection of: Restriction
    on property: has plasma membrane part
    some values from: killer cell lectin-like receptor subfamily B member 1C
  intersection of: Restriction
    on property: only in taxon
    some values from: Mus musculus
subclass of: mature natural killer cell
definition: A mature NK cell that is NK1.1-positive.
created_by: tmeehan
creation_date: 2010-10-25T03:18:04Z
has_exact_synonym: NK.sp
has_exact_synonym: NK1.1-positive NK cell
has_obo_namespace: cell
comment: Note: Nk1.1 expression is restricted to C57BL strains of laboratory mice.

Axiom
annotated source: NK1.1-positive natural killer cell
annotated property: definition
annotated target: A mature NK cell that is NK1.1-positive.
database_cross_reference: GOC:tfm

NKGA2-positive natural killer cell
type: Class
equivalent class: Class
  intersection of: NK1.1-positive natural killer cell
  intersection of: Restriction
    on property: has plasma membrane part
    some values from: NKG2-A/NKG2-B type II integral membrane protein
  intersection of: Restriction
    on property: only in taxon
    some values from: Mus musculus
subclass of: NK1.1-positive natural killer cell
definition: A NK1.1-positive T cell that is NKGA2-positive.
created_by: tmeehan
creation_date: 2010-10-25T03:31:09Z
has_exact_synonym: NK.G2A+.SP
has_obo_namespace: cell

Axiom
annotated source: NKGA2-positive natural killer cell
annotated property: definition
annotated target: A NK1.1-positive T cell that is NKGA2-positive.
database_cross_reference: GOC:tfm
database_cross_reference: http://www.immgen.org/index_content.html

Ly49D-positive natural killer cell
type: Class
equivalent class: Class
  intersection of: NK1.1-positive natural killer cell
  intersection of: Restriction
    on property: has plasma membrane part
    some values from: killer cell lectin-like receptor 4
  intersection of: Restriction
    on property: only in taxon
    some values from: Mus musculus
subclass of: NK1.1-positive natural killer cell
definition: A NK1.1-positive T cell that is Ly49D-positive.
created_by: tmeehan
creation_date: 2010-10-25T03:36:19Z
has_exact_synonym: NK.49D+.Sp
has_obo_namespace: cell

Axiom
annotated source: Ly49D-positive natural killer cell
annotated property: definition
annotated target: A NK1.1-positive T cell that is Ly49D-positive.
database_cross_reference: GOC:tfm
database_cross_reference: http://www.immgen.org/index_content.html

CD94-positive natural killer cell
type: Class
equivalent class: Class
  intersection of: NK1.1-positive natural killer cell
  intersection of: Restriction
    on property: has plasma membrane part
    some values from: killer cell lectin-like receptor subfamily D member 1
  intersection of: Restriction
    on property: only in taxon
    some values from: Mus musculus
subclass of: NK1.1-positive natural killer cell
definition: A NK1.1-positive T cell that is CD94-positive.
created_by: tmeehan
creation_date: 2010-10-25T03:36:28Z
has_exact_synonym: NK.94+.Sp
has_obo_namespace: cell

Axiom
annotated source: CD94-positive natural killer cell
annotated property: definition
annotated target: A NK1.1-positive T cell that is CD94-positive.
database_cross_reference: GOC:tfm
database_cross_reference: http://www.immgen.org/index_content.html

CD94-negative, Ly49CI-negative natural killer cell
type: Class
equivalent class: Class
  intersection of: natural killer cell
  intersection of: Restriction
    on property: only in taxon
    some values from: Mus musculus
  intersection of: Restriction
    on property: lacks_plasma_membrane_part
    some values from: killer cell lectin-like receptor subfamily D member 1
  intersection of: Restriction
    on property: lacks_plasma_membrane_part
    some values from: killer cell lectin-like receptor 3
subclass of: Ly49CI-negative natural killer cell
subclass of: CD94-negative natural killer cell
definition: A NK1.1-positive T cell that is CD94-negative and Ly49Cl-negative.
created_by: tmeehan
creation_date: 2010-10-25T03:56:21Z
has_exact_synonym: CD94- Ly49I-negative NK cell
has_exact_synonym: NK.49Cl-94-.Sp
has_obo_namespace: cell

Axiom
annotated source: CD94-negative, Ly49CI-negative natural killer cell
annotated property: definition
annotated target: A NK1.1-positive T cell that is CD94-negative and Ly49Cl-negative.
database_cross_reference: GOC:tfm
database_cross_reference: http://www.immgen.org/index_content.html

Ly49CI-positive natural killer cell
type: Class
equivalent class: Class
  intersection of: NK1.1-positive natural killer cell
  intersection of: Restriction
    on property: has plasma membrane part
    some values from: killer cell lectin-like receptor 3
  intersection of: Restriction
    on property: only in taxon
    some values from: Mus musculus
subclass of: NK1.1-positive natural killer cell
definition: A NK1.1-positive T cell that is Ly49Cl-positive.
created_by: tmeehan
creation_date: 2010-10-25T03:36:38Z
has_exact_synonym: Ly49I-positive NK cell
has_exact_synonym: NK.49Cl+.Sp
has_obo_namespace: cell

Axiom
annotated source: Ly49CI-positive natural killer cell
annotated property: definition
annotated target: A NK1.1-positive T cell that is Ly49Cl-positive.
database_cross_reference: GOC:tfm
database_cross_reference: http://www.immgen.org/index_content.html

Ly49H-positive natural killer cell
type: Class
equivalent class: Class
  intersection of: NK1.1-positive natural killer cell
  intersection of: Restriction
    on property: has plasma membrane part
    some values from: killer cell lectin-like receptor 8
  intersection of: Restriction
    on property: only in taxon
    some values from: Mus musculus
subclass of: NK1.1-positive natural killer cell
definition: A NK1.1-positive T cell that is Ly49H-positive.
created_by: tmeehan
creation_date: 2010-10-25T03:36:43Z
has_exact_synonym: LyH49H-positive
has_obo_namespace: cell

Axiom
annotated source: Ly49H-positive natural killer cell
annotated property: definition
annotated target: A NK1.1-positive T cell that is Ly49H-positive.
database_cross_reference: GOC:tfm
database_cross_reference: http://www.immgen.org/index_content.html

Ly49D-negative natural killer cell
type: Class
equivalent class: Class
  intersection of: NK1.1-positive natural killer cell
  intersection of: Restriction
    on property: only in taxon
    some values from: Mus musculus
  intersection of: Restriction
    on property: lacks_plasma_membrane_part
    some values from: killer cell lectin-like receptor 4
subclass of: NK1.1-positive natural killer cell
definition: A NK1.1-positive T cell that is Ly49D-negative.
created_by: tmeehan
creation_date: 2010-10-25T03:39:02Z
has_exact_synonym: NK.49D-.Sp
has_obo_namespace: cell

Axiom
annotated source: Ly49D-negative natural killer cell
annotated property: definition
annotated target: A NK1.1-positive T cell that is Ly49D-negative.
database_cross_reference: GOC:tfm
database_cross_reference: http://www.immgen.org/index_content.html

Ly49CI-negative natural killer cell
type: Class
equivalent class: Class
  intersection of: NK1.1-positive natural killer cell
  intersection of: Restriction
    on property: only in taxon
    some values from: Mus musculus
  intersection of: Restriction
    on property: lacks_plasma_membrane_part
    some values from: killer cell lectin-like receptor 3
subclass of: NK1.1-positive natural killer cell
definition: A NK1.1-positive T cell that is Ly49Cl-negative.
created_by: tmeehan
creation_date: 2010-10-25T03:52:04Z
has_exact_synonym: Ly49I-negative NK cell
has_exact_synonym: NK.49Cl-.Sp
has_obo_namespace: cell

Axiom
annotated source: Ly49CI-negative natural killer cell
annotated property: definition
annotated target: A NK1.1-positive T cell that is Ly49Cl-negative.
database_cross_reference: GOC:tfm
database_cross_reference: http://www.immgen.org/index_content.html

CD94-negative natural killer cell
type: Class
equivalent class: Class
  intersection of: NK1.1-positive natural killer cell
  intersection of: Restriction
    on property: only in taxon
    some values from: Mus musculus
  intersection of: Restriction
    on property: lacks_plasma_membrane_part
    some values from: killer cell lectin-like receptor subfamily D member 1
subclass of: NK1.1-positive natural killer cell
definition: A NK1.1-positive T cell that is CD94-negative.
created_by: tmeehan
creation_date: 2010-10-25T03:54:18Z
has_exact_synonym: NK.94-.Sp
has_obo_namespace: cell

Axiom
annotated source: CD94-negative natural killer cell
annotated property: definition
annotated target: A NK1.1-positive T cell that is CD94-negative.
database_cross_reference: GOC:tfm
database_cross_reference: http://www.immgen.org/index_content.html

Ly49H-negative natural killer cell
type: Class
equivalent class: Class
  intersection of: NK1.1-positive natural killer cell
  intersection of: Restriction
    on property: only in taxon
    some values from: Mus musculus
  intersection of: Restriction
    on property: lacks_plasma_membrane_part
    some values from: killer cell lectin-like receptor 8
subclass of: NK1.1-positive natural killer cell
definition: A NK1.1-positive T cell that is Ly49H-negative.
created_by: tmeehan
creation_date: 2010-10-25T03:42:42Z
has_exact_synonym: LyH49H-negative
has_obo_namespace: cell

Axiom
annotated source: Ly49H-negative natural killer cell
annotated property: definition
annotated target: A NK1.1-positive T cell that is Ly49H-negative.
database_cross_reference: GOC:tfm
database_cross_reference: http://www.immgen.org/index_content.html

CD94-positive Ly49CI-positive natural killer cell
type: Class
equivalent class: Class
  intersection of: NK1.1-positive natural killer cell
  intersection of: Restriction
    on property: has plasma membrane part
    some values from: killer cell lectin-like receptor subfamily D member 1
  intersection of: Restriction
    on property: has plasma membrane part
    some values from: killer cell lectin-like receptor 3
  intersection of: Restriction
    on property: only in taxon
    some values from: Mus musculus
subclass of: CD94-positive natural killer cell
subclass of: Ly49CI-positive natural killer cell
definition: A NK1.1-positive T cell that is CD94-positive and Ly49Cl-positive.
created_by: tmeehan
creation_date: 2010-10-25T03:56:27Z
has_exact_synonym: NK.49Cl+94+.Sp
has_obo_namespace: cell

Axiom
annotated source: CD94-positive Ly49CI-positive natural killer cell
annotated property: definition
annotated target: A NK1.1-positive T cell that is CD94-positive and Ly49Cl-positive.
database_cross_reference: GOC:tfm
database_cross_reference: http://www.immgen.org/index_content.html

hepatic pit cell
type: Class
subclass of: natural killer cell
subclass of: Restriction
  on property: located in
  some values from: hepatic sinusoid
definition: A large, granular, liver specific natural killer cell that adheres to the endothelial cells of the hepatic sinusoid.
has_obo_namespace: cell
comment: Pit cells are named for the presence of large cytoplasmic granules that resemble pits (pips) of fruit.

Axiom
annotated source: hepatic pit cell
annotated property: definition
annotated target: A large, granular, liver specific natural killer cell that adheres to the endothelial cells of the hepatic sinusoid.
database_cross_reference: GOC:dos
database_cross_reference: PMID:9408963

heterochromatin
type: Class
subclass of: cell part

cytokine production
type: Class
subclass of: biological process

leukocyte mediated cytotoxicity
type: Class
subclass of: biological process

natural killer cell mediated immunity
type: Class
subclass of: biological process

positive regulation of type 2 immune response
type: Class
subclass of: biological process

biological process
type: Class
subclass of: Thing

secretory granule
type: Class
subclass of: cell part

interferon-gamma production
type: Class
subclass of: biological process

interleukin-13 production
type: Class
subclass of: biological process

interleukin-5 production
type: Class
subclass of: biological process

alpha-beta T cell receptor complex
type: Class
subclass of: cell part

natural killer cell mediated cytotoxicity
type: Class
subclass of: biological process

cell part
type: Class
subclass of: Thing

innate immune response
type: Class
subclass of: biological process

regulation of immune response
type: Class
subclass of: biological process

Mus musculus
type: Class
subclass of: Metazoa

Eukaryota
type: Class
subclass of: Thing

Metazoa
type: Class
subclass of: Eukaryota

Homo sapiens
type: Class
subclass of: Metazoa

immature
type: Class
subclass of: Thing

protein
type: Class
subclass of: Thing

CD19 molecule
type: Class
subclass of: protein

CD34 molecule
type: Class
subclass of: protein

CD4 molecule
type: Class
subclass of: protein

integrin alpha-2
type: Class
subclass of: protein

integrin alpha-M
type: Class
subclass of: protein

CD3 epsilon
type: Class
subclass of: protein

neural cell adhesion molecule 1
type: Class
subclass of: protein

T-cell surface glycoprotein CD8 alpha chain
type: Class
subclass of: protein

membrane-spanning 4-domains subfamily A member 1
type: Class
subclass of: protein

SLAM family member 5
type: Class
subclass of: protein

bone marrow stromal antigen 2
type: Class
subclass of: protein

interleukin-2 receptor subunit beta
type: Class
subclass of: protein

killer cell lectin-like receptor subfamily D member 1
type: Class
subclass of: protein

low affinity immunoglobulin gamma Fc region receptor III
type: Class
subclass of: protein

inducible T-cell costimulator
type: Class
subclass of: protein

interleukin-7 receptor subunit alpha
type: Class
subclass of: protein

KLRB1-like protein
type: Class
subclass of: protein

CD14 molecule
type: Class
subclass of: protein

natural cytotoxicity triggering receptor 1
type: Class
subclass of: protein

sialic acid-binding Ig-like lectin 5
type: Class
subclass of: protein

CD27 molecule
type: Class
subclass of: protein

MHC class II histocompatibility antigen alpha chain DRA
type: Class
subclass of: protein

NKG2-A/NKG2-B type II integral membrane protein
type: Class
subclass of: protein

mast/stem cell growth factor receptor
type: Class
subclass of: protein

killer cell lectin-like receptor subfamily B member 1C
type: Class
subclass of: protein

nuclear receptor ROR-gamma isoform 2
type: Class
subclass of: protein

high affinity immunoglobulin epsilon receptor subunit alpha
type: Class
subclass of: protein

interleukin-17 receptor B
type: Class
subclass of: protein

interleukin-1 receptor-like 1
type: Class
subclass of: protein

T-cell surface glycoprotein YE1/48
type: Class
subclass of: protein

killer cell lectin-like receptor 3
type: Class
subclass of: protein

killer cell lectin-like receptor 4
type: Class
subclass of: protein

killer cell lectin-like receptor 8
type: Class
subclass of: protein

galectin-1
type: Class
subclass of: protein

natural cytotoxicity triggering receptor 1 (human)
type: Class
subclass of: protein

natural cytotoxicity triggering receptor 2 (human)
type: Class
subclass of: protein

interleukin-2 receptor subunit alpha (human)
type: Class
subclass of: protein

mast/stem cell growth factor receptor Kit (human)
type: Class
subclass of: protein

neural cell adhesion molecule 1 (human)
type: Class
subclass of: protein

interleukin-7 receptor subunit alpha (human)
type: Class
subclass of: protein

trans-acting T-cell-specific transcription factor GATA-3 (human)
type: Class
subclass of: protein

hematopoietic progenitor cell antigen CD34 (human)
type: Class
subclass of: protein

early activation antigen CD69 (human)
type: Class
subclass of: protein

killer cell lectin-like receptor subfamily B member 1 (human)
type: Class
subclass of: protein

killer cell lectin-like receptor subfamily G member 1 (human)
type: Class
subclass of: protein

T-box transcription factor TBX21 (human)
type: Class
subclass of: protein

anatomical entity
type: Class
subclass of: Thing

hepatic sinusoid
type: Class
subclass of: anatomical entity