Validation report

ID OBO Namespace Label Exact Synonym Exact Synonym with Reference Synonym Reference Broad Synonym Synonym Reference Related Synonym Synonym Reference Database Cross Reference Definition Definition Source Comment OBO Creator OBO Creation Date DC Creator DC Creation Date Class Type Parent Asserted Parent Disjoint With Capable Of Has Plasma Membrane Part Lacks Plasma Membrane Part High Amount Low Amount Develops From Other Axioms
is-required true; subclass-of 'cell'
CL:0001065 cell innate lymphoid cell A lymphocyte that lacks characteristic T cell, B cell, myeloid cell, and dendritic cell markers, that functions as part of the innate immune response to produce cytokines and other effector responses. GOC:add|GOC:dsd|PMID:23292121|PMID:23348417 http://orcid.org/0000-0001-9990-8331 2017-01-30T20:20:48Z equivalent lymphocyte cytokine production|innate immune response CD19 molecule|CD3 epsilon
CL:0001067 cell group 1 innate lymphoid cell An innate lymphoid cell that is capable of producing the type 1 cytokine IFN-gamma, but not Th2 or Th17 cell-associated cytokines. GOC:add|GOC:dsd|PMID:23348417 http://orcid.org/0000-0001-9990-8331 2017-01-30T20:42:44Z equivalent innate lymphoid cell interferon-gamma production
CL:0001068 cell ILC1 A group 1 innate lymphoid cell that is non-cytotoxic. GOC:add|GOC:dsd|PMID:23292121|PMID:23348417 http://orcid.org/0000-0001-9990-8331 2017-01-30T20:54:12Z equivalent group 1 innate lymphoid cell (not ('capable of' some 'leukocyte mediated cytotoxicity'))
CL:0000623 cell natural killer cell NK cell large granular lymphocyte|null cell VHOG:0001697|FMA:63147|CALOHA:TS-0664|BTO:0004716|FMA:83601|BTO:0000914 A lymphocyte that can spontaneously kill a variety of target cells without prior antigenic activation via germline encoded activation receptors and also regulate immune responses via cytokine release and direct contact with other cells. GOC:add|ISBN:0781735149|PMID:15771571 equivalent group 1 innate lymphoid cell natural killer cell mediated immunity|regulation of immune response CD19 molecule|CD3 epsilon|membrane-spanning 4-domains subfamily A member 1|CD14 molecule pro-NK cell
CL:2000054 cell hepatic pit cell A large, granular, liver specific natural killer cell that adheres to the endothelial cells of the hepatic sinusoid. GOC:dos|PMID:9408963 Pit cells are named for the presence of large cytoplasmic granules that resemble pits (pips) of fruit. subclass natural killer cell ('located in' some 'hepatic sinusoid')
CL:0000823 cell immature natural killer cell immature NK cell p-NK PMID:12457618 A natural killer cell that is developmentally immature and expresses natural killer cell receptors (NKR). GOC:add|GO_REF:0000031|ISBN:0781735149|PMID:12457618 In mouse the NKR are Ly49 molecules and in human these cells express KIR molecules. equivalent natural killer cell mature natural killer cell|pre-natural killer cell pre-natural killer cell ('bearer of' some immature)
CL:0000824 cell mature natural killer cell mature NK cell LAK cell|lymphokine activated killer cell PMID:14685782 A natural killer cell that is developmentally mature and expresses a variety of inhibitory and activating receptors that recognize MHC class I and other stress related molecules. GOC:add|GO_REF:0000031|ISBN:0781735149|PMID:14685782 subclass natural killer cell immature natural killer cell
CL:0000937 cell pre-natural killer cell pre-NK cell Cell committed to natural killer cell lineage that has the phenotype CD122-positive, CD34-positive, and CD117-positive. This cell type lacks expression of natural killer receptor proteins. GOC:add|GOC:dsd|GOC:pam|GOC:tfm|GO_REF:0000031|PMID:16551251|PMID:17100874 These cells are also reportedly CD7-low, CD10-negative, CD45RA-positive, alpha-4-beta-7 integrin-high. equivalent natural killer cell CD34 molecule|interleukin-2 receptor subunit beta|mast/stem cell growth factor receptor
CL:0001069 cell group 2 innate lymphoid cell ILC2|nuocyte An innate lymphoid cell that is capable of producing T-helper 2-cell associated cytokines upon stimulation. GOC:add|GOC:dsd|PMID:23292121|PMID:23562755 http://orcid.org/0000-0001-9990-8331 2017-01-30T21:20:08Z equivalent innate lymphoid cell interleukin-5 production
CL:0001071 cell group 3 innate lymphoid cell ILC3 An innate lymphoid cell that constituitively expresses RORgt and is capable of expressing IL17A and/or IL-22. GOC:add|GOC:dsd|PMID:23292121|PMID:23348417 http://orcid.org/0000-0001-9990-8331 2017-01-31T20:21:26Z equivalent innate lymphoid cell ('has part' some 'nuclear receptor ROR-gamma isoform 2')
CL:0001082 immature innate lymphoid cell immature ILC An innate lyphoid cell with an immature phenotype. GOC:add equivalent innate lymphoid cell ('bearer of' some immature)